Diet and exercise are important to keep blood glucose under control, but often they’re not enough. Why? As we age, get exposed to different environments and different stresses, our bodies lose specific beneficial bacteria that allow it to process carbohydrates, sugars and fibers effectively. These beneficial bacteria live along the length of your digestive tract and ready your body for the sugars that are on the way by starting the metabolism process.

Through years of research, Whole Biome has pinpointed these beneficial bacteria that go missing in type 2 diabetes and developed Whole Biome T2D.

Why Your Body Struggles to Control Blood Sugar

As we digest carbohydrates and sugars, our bodies naturally produce insulin, whose role is to transport glucose out of the blood stream for the body to use as energy or to store as fat.

However, people with type 2 diabetes suffer from the inability to effectively use insulin. As a result, the body struggles to keep blood sugar levels under control.

Butyrate - The Beneficial Metabolite

What can you do to help your body process insulin effectively again? Your body needs to produce butyrate, a naturally-occurring molecule that has been shown to help your body use insulin more effectively.

The good news? Whole Biome has identified the precise strains of probiotics (friendly live microorganisms) and prebiotics (food to fuel microorganism) that your body needs to produce butyrate and in turn, allow your insulin to work effectively again.

The Solution?
Live Synbiotics™ in Whole Biome T2D

Our Live Synbiotics™ formula contains precise strains of probiotics (friendly live microorganisms) and prebiotics (food to fuel microorganism). This combination fuels your ecosystem, enabling your body to produce butyrate and process insulin more efficiently to help digest carbs and sugar. Whole Biome T2D is the first product shown to effectively restore the missing beneficial bacteria using naturally-occurring ingredients.

How Live Synbiotics™ Formulation Works:

Grow Beneficial Bacteria

We are pioneering a new way to manage chronic disease through the human microbiome – the home to trillions of microorganism that live in your stomach, small intestine, and colon.

Improve Blood Sugar Levels

Starts a cascade reaction towards a healthy digestion of carbohydrates and sugars.

Improve Gut Lining

Butyrate helps to protect the gut lining in your intestines by preventing bad bacteria from contaminating your gut.

Improve Fiber Potential

Not found in typical probiotics (i.e. yogurt & fermented foods), our Live Synbiotics™ break down the fiber and produce beneficial molecules that energize the cells in your colon.

Clinical Research Shows Effectiveness

In a clinical trial, Whole Biome T2D was shown to significantly lower A1C levels and reduce post-meal blood sugar spikes in consumers with Type 2 Diabetes, including those taking a first time prescription medicine for their condition.

A1C Results

Shown to lower A1C after 12 Weeks*

Blood Glucose Results

Shown to significantly lower blood glucose in response to meals
*Statistically significant reduction in HbA1C and blood sugar spikes in people with Type 2 Diabetes, in a randomized, double-blinded, placebo-controlled clinical trial across multiple sites in the United States.

Whole Biome T2D Effectiveness Compared to other Diabetes Management Solutions


1. A metagenome-wide association study of gut microbiota in type 2 diabetes Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. Nature (2012) 490:55–60. doi: 10.1038/nature11450


2. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome Vrieze A., Van Nood E., Holleman F., Salojärvi J., Kootte R.S., Bartelsman J.F., Dallinga-Thie G.M., Ackermans M.T., Serlie M.J., Oozeer R., et al. Gastroenterology.



3. Gut metagenome in European women with normal, impaired and diabetic glucose control. Karlsson F.H., Tremaroli V., Nookaew I., Bergström G., Behre C.J., Fagerberg B., Nielsen J., Bäckhed F. Nature. 2013

4. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, et al. Nature (2015) 528:262–6.


5. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptorFFAR2. Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, et al. Diabetes (2013) 61:364–71.

6. Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice. Xu YH, Gao CL, Guo HL, Zhang WQ, Huang W, Tang SS, et al. J Endocrinol. (2018) 238:231–44.

7. A dietary intervention with functional foods reduces metabolic endotoxaemia and attenuates biochemical abnormalities by modifying faecal microbiota in people with type 2 diabetes. Medina-Vera, I.; Sanchez-Tapia, M.; Noriega-Lopez, L.; Granados-Portillo, O.; Guevara-Cruz, M.; Flores-Lopez, A.; Avila-Nava, A.; Fernandez, M.L.; Tovar, A.R.; Torres, N. Diabetes Metab. 2018.

8. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Zhao, L.; Zhang, F.; Ding, X.; Wu, G.; Lam, Y.Y.; Wang, X.; Fu, H.; Xue, X.; Lu, C.; Ma, J.; et al. Science 2018, 359, 1151–1156.

9. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011;17(12):1519-28.

10. Improvement of Insulin Sensitivity after Lean Donor Faeces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. Kootte R.S., Levin E., Salojärvi J., Smits L.P., Hartstra A.V., Udayappan S.D., Hermes G., Bouter K.E., Koopen A.M., Holst J.J., et al. Cell Metab. 2017:611–619.